“We love you Phil,” Hetfield said in tribute to the late singer and bassist.
The band dug up the 'St. Anger' classic for the opening night of their latest run of WorldWired tour dates.
The show will be the first concert at San Francisco's Chase Center, and will mark the 20th anniversary of 'S&M.'
Other artists on hand to pay their respects to the late singer and guitarist included members of Pearl Jam, Alice in Chains, Black Sabbath and more.
Radically-reworked version of the 'Master of Puppets' classic features mandolin, pedal steel and keyboards.
'Play It Loud' will feature Eddie Van Halen's "Frankenstein," Eric Clapton's "Blackie," and many more legendary instruments.